Estimation of Mediation Effect on Zero-Inflated Microbiome Mediators

نویسندگان

چکیده

The mediation analysis methodology of the cause-and-effect relationship through mediators has been increasingly popular over past decades. human microbiome can contribute to pathogenesis many complex diseases by mediating disease-leading causal pathways. However, standard is not adequate for data due excessive number zero values and over-dispersion in sequencing reads, which arise both biological sampling reasons. To address these unique challenges brought zero-inflated mediator, we developed a novel algorithm under potential-outcome framework fill this gap. proposed semiparametric model estimates effect decomposing indirect effects into two components according distributions. bootstrap utilized calculate empirical confidence intervals effects. We conducted extensive simulation studies investigate performance weighting-based approach some model-based alternatives, our showed robust performance. was implemented real study identifying whether taxa mediate between LACTIN-V treatment immune response.

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ژورنال

عنوان ژورنال: Mathematics

سال: 2023

ISSN: ['2227-7390']

DOI: https://doi.org/10.3390/math11132830